Vitamin D3 5,000 IU for Healthy Bones, Teeth, Heart and Immune Support, Non-GMO, Gluten-Free, Soy Free, 360 Count Pack

Vitamin d from dietary intake or sun exposure requires two activation steps in the body. The first step takes place in the liver, and the second occurs in the kidneys, allowing for the regulation of calcium metabolism. However, vitamin d receptors are present throughout the body in tissue such as the skin, cartilage, heart, prostate, bones, and intestines. Thus, the second activation step also occurs in local tissues. Recent discoveries have highlighted the important modulatory effects of vitamin d on various cells of the immune system, enhancing and regulating immune function. It is known that various cells of the immune system, such as t lymphocytes and antigen presenting cells, express the vitamin d receptor on their surface when activated. Treatment with vitamin d influences their expression of cytokines, which are chemical messengers of the immune system. The immune modulating effects of vitamin d extend to monocytes and dendritic cells of the immune system as well. Dendritic cells are important antigen-processing cells of the immune system that function to initiate the immune response. Vitamin d may prevent overactivity of the immune response and keep the immune system in a normal healthy state of vigilance.

Vitamin d also supports optimal cardiovascular function. Research has uncovered the role vitamin d plays in supporting cardiac function. Heart myocytes (cells) express the vitamin d receptor, as do smooth muscle cells of blood vessels. The benefits of vitamin d on the heart are potentially far-reaching. Studies have shown that vitamin d administration impacts the growth and proliferation of mice heart cells. Vitamin d inhibited the release of a protein that could be detrimental to the function of these cells, displaying cardioprotective properties. It has also been shown that vitamin d has a modulatory effect on heart rhythm.

Vitamin D, also known as the "Sunshine Vitamin," supports healthy bone density and structure, and is required for optimal calcium absorption. Exposure to heat or sunlight may lead to melting/damage of the product. Hence, customers are expected to be available during product delivery. Approximately 75% of Americans are deficient in vitamin D. Some researchers suggest that a minimum daily intake of 1,000 IU is necessary to maintain barely adequate blood levels of vitamin D. Others agree that much higher doses are needed to ensure levels are optimal enough to promote health.

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